Friday, March 29, 2024 | 13:04 WIB

Hepatocyte therapy spells more effective hepatitis treatment

READ MORE

Melinda Remelia, S.Si., M.Biomed.
Melinda Remelia, S.Si., M.Biomed. (Source: FKUI)

Melinda’s dissertation, titled “Direct Reprogramming of Human Primary Fibroblast into Hepatocyte – like Cells by Transcription of Cebpa, Hnf4a, and Nr1i2 Factors”, was awarded an “A”, with a GPA score of 3.89. 

Recombinant Peptide Delivery System 

The tissue’s fibroblast cells are separated from the overall tissue, then multiplied using cell culture in a laboratory. Direct programming is performed by inserting the Cebpa, Hnf4a, and Nr1i2 transcription factor DNAs into the fibroblast cells. This technique is safe for patients, as the expression employs a separate system that prevents DNA mutation or sequence change in the fibroblast, which could trigger the formation of cancerous cells instead. 

Read: Improve access to early detection for hepatitis

“This study innovates by using the ALMR recombinant peptide delivery system when inserting the transcription factor, making it safer than the viral delivery system commonly used. Furthermore, the process of transforming fibroblast cells into hepatocyte cells is performed directly, without undergoing any cellular pluripotent stage, which avoids the possibility of forming tumor cells,” the biomedical researcher said. 

POPULAR

Latest article

Related Articles

INFRAME

SOCIAL CULTURE